BLEEDING NEWS'21

First-Line Administration of Fibrinogen Concentrate in the Bleeding Trauma Patient: Searching for Effective Dosages and Optimal Post-Treatment Levels Limiting Massive Transfusion-Further Results of the RETIC Study.
Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial.
Dynamics of Platelet Counts in Major Trauma: The Impact of Haemostatic Resuscitation and Effects of Platelet Transfusion-A Sub-Study of the Randomized Controlled RETIC Trial.

Monográfico III: Anticoagulación y riesgo de sangrado en la terapia de oxigenación extracorpórea.

Fibrinógeno en la reanimación inicial de trauma severo (FiiRST): un ensayo de viabilidad aleatorio
Evaluación de la coagulopatía inducida por trauma en el fibrinógeno en la reanimación inicial del ensayo de trauma severo
Algoritmo de tratamiento simplificado para el manejo de la hemorragia inducida por trauma sin pruebas viscoelásticas

A meta-analysis of andexanet alfa and prothrombin complex concentrate in the treatment of factor Xa inhibitor-related major bleeding
Prothrombin complex concentrate in major bleeding associated with DOACs; an updated systematic review and meta-analysis
Treatment of adults with intracranial hemorrhage on apixaban or rivaroxaban with prothrombin complex concentrate products

Altered Fibrinolysis during and after Surgery
The concept of rebalanced hemostasis in patients with liver disease: Communication from the ISTH SSC working group on hemostatic management of patients with liver disease
Role of fibrinogen concentrates for treatment of critical perioperative hemorrhage

Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis
Red blood cell transfusion in obstetrics and its implication for patient blood management: a retrospective analysis in Switzerland from 1998 to 2016
Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference

Variations and obstacles in the use of coagulation factor concentrates for major trauma bleeding across Europe: outcomes from a European expert meeting
Institution of prothrombin complex concentrate protocols is associated with a reduction in plasma administration at a Tertiary Care Hospital
Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review